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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
31.21
Human Site:
S158
Identified Species:
49.05
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
S158
N
H
F
G
R
S
M
S
V
E
K
I
D
I
S
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
S158
N
H
F
G
R
S
M
S
V
E
K
I
D
I
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
S158
N
H
F
G
R
S
M
S
V
E
K
I
D
I
S
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
S158
N
H
F
G
R
S
M
S
V
E
K
V
D
I
S
Rat
Rattus norvegicus
Q9JIM0
706
80103
S158
N
H
F
G
R
S
M
S
V
E
K
V
D
I
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
S158
N
H
F
G
R
S
M
S
V
E
K
I
D
I
S
Chicken
Gallus gallus
Q9IAM7
700
80005
S158
N
H
F
G
R
S
T
S
V
E
K
I
D
I
S
Frog
Xenopus laevis
Q9W6K1
711
81112
S159
N
H
F
G
R
A
T
S
V
E
K
I
D
I
S
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
L145
G
L
C
A
V
D
L
L
S
C
A
G
L
V
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
L146
R
L
S
S
L
D
L
L
S
T
S
G
L
V
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
I211
L
F
G
K
H
S
N
I
Q
E
F
I
V
S
P
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
R44
E
E
I
L
Q
L
A
R
K
N
K
V
D
M
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
G155
Y
F
G
K
M
V
L
G
G
S
G
V
G
Q
I
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
E154
N
H
F
G
K
V
I
E
S
D
K
I
K
V
V
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
E153
N
Y
F
G
R
V
P
E
A
D
N
I
H
V
K
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
100
N.A.
100
N.A.
93.3
93.3
N.A.
100
93.3
86.6
0
N.A.
0
N.A.
20
13.3
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
93.3
93.3
20
N.A.
20
N.A.
20
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
0
40
33.3
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
66.6
53.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
7
7
0
7
0
7
0
0
0
0
% A
% Cys:
0
0
7
0
0
0
0
0
0
7
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
14
0
0
0
14
0
0
60
0
0
% D
% Glu:
7
7
0
0
0
0
0
14
0
60
0
0
0
0
0
% E
% Phe:
0
14
67
0
0
0
0
0
0
0
7
0
0
0
0
% F
% Gly:
7
0
14
67
0
0
0
7
7
0
7
14
7
0
0
% G
% His:
0
60
0
0
7
0
0
0
0
0
0
0
7
0
0
% H
% Ile:
0
0
7
0
0
0
7
7
0
0
0
60
0
54
7
% I
% Lys:
0
0
0
14
7
0
0
0
7
0
67
0
7
0
7
% K
% Leu:
7
14
0
7
7
7
20
14
0
0
0
0
14
0
0
% L
% Met:
0
0
0
0
7
0
40
0
0
0
0
0
0
7
0
% M
% Asn:
67
0
0
0
0
0
7
0
0
7
7
0
0
0
14
% N
% Pro:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
7
% P
% Gln:
0
0
0
0
7
0
0
0
7
0
0
0
0
7
0
% Q
% Arg:
7
0
0
0
60
0
0
7
0
0
0
0
0
0
0
% R
% Ser:
0
0
7
7
0
54
0
54
20
7
7
0
0
7
54
% S
% Thr:
0
0
0
0
0
0
14
0
0
7
0
0
0
0
0
% T
% Val:
0
0
0
0
7
20
0
0
54
0
0
27
7
27
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _